The time it takes to feel improvement after starting Ocrevus (ocrelizumab) can vary depending on your condition (e.g., relapsing-remitting MS [RRMS] or primary progressive MS [PPMS]) and individual response. Here’s a general timeline:
Typical Ocrevus Infusion Schedule & When Benefits May Appear:
- First Two Infusions (Initial Doses):
- Dose 1: 300 mg (first half-dose)
- Dose 2: 300 mg (second half-dose, 2 weeks later)
- These first two infusions help reduce the risk of infusion reactions but usually do not provide immediate symptom relief.
- First Full Dose (600 mg, 6 months after initial doses):
- Many patients begin noticing stabilization of symptoms (fewer relapses, slower progression) within 3–6 months after the first full dose.
- Some may feel subtle improvements in fatigue or mobility, but dramatic changes are less common.
- Subsequent Infusions (Every 6 Months):
- Continued benefits (e.g., fewer relapses, slower disability progression) typically become more noticeable after 12–18 months of treatment.
- PPMS patients may take longer to observe effects since Ocrevus primarily slows progression rather than reversing symptoms.
Factors That Influence Response:
- Disease activity level before starting treatment
- Previous treatments (if switching from another therapy)
- Individual variability in immune response
When to Expect Noticeable Changes?
- Early (1–6 months): Reduced inflammatory activity (seen on MRI)
- 6–12 months: Fewer relapses (for RRMS), possible symptom stabilization
- Beyond 1 year: Slowed disability progression (especially in PPMS)
Important Notes:
- Ocrevus is not a cure—it works to slow disease progression rather than reverse existing damage.
- Some symptoms (e.g., fatigue, weakness) may improve, while others (e.g., permanent nerve damage) may not.
- If you don’t feel improvement after 12–18 months, discuss alternatives with your neurologist.